Electrophysiological studies on oxindole, a neurodepressant tryptophan metabolite
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چکیده
منابع مشابه
Tryptophan metabolite excretion by the American cockroach.
Abstrac t -1 . Three fluorescing materials have been discovered in excreta from the American cockroach, Periplaneta americana (L.), and found to increase in concentration as dietary nitrogen increases. 2. These compounds have been identified as kynurenic, xanthurenic and 8-hydroxyquinaldic acids. 3. Feeding cockroaches antibiotic eliminates 8-hydroxyquinaldic acid production, presumably by inhi...
متن کاملTreatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite.
Local catabolism of the amino acid tryptophan (Trp) by indoleamine 2,3-dioxygenase (IDO) is considered an important mechanism of regulating T cell immunity. We show that IDO transcription was increased when myelin-specific T cells were stimulated with tolerogenic altered self-peptides. Catabolites of Trp suppressed proliferation of myelin-specific T cells and inhibited production of proinflamma...
متن کاملAbsorption studies on tryptophan and acetyltryptophan.
Many investigations have demonstrated that amino acids are absorbed by enzymatic processes (l-3). Recent investigations on the fate of ingested acetyl-L-tryptophan (4) showed that the rate of absorption of this isomer is much slower than that reported previously for an equivalent amount of free n-tryptophan (5). du Vigneaud et al. (6) found, however, that the acetylated analogue is utilized equ...
متن کاملElectrophysiological studies on the intestinal intrinsic reflex.
HUKUHARA, YAMAGAMI and NAKAYAMA7) have reported that the intestinal reflex consists of two kinds, the mucosal and muscular reflexes, distinctly different in nature from each other. In the former the mechanical or the chemical stimulation of the mucosa produces excitation above and inhibition below the stimulated spot, and in the latter the mechanical or the chemical stimulation of the muscular ...
متن کاملInhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases.
KYNA (kynurenic acid) is an endogenous metabolite of tryptophan in the kynurenine pathway and has been characterized as an antagonist of ionotropic glutamate receptors. In addition, we have reported this endogenous compound as a potent inhibitor of SULTs (cytosolic sulfotransferases). In the present study we characterized the inhibitory effects of KYNA on several human (h) and mouse (m) recombi...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1998
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0702241